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Epigenome and transcriptome of naive pluripotent mouse embryonic stem (ES) cells cultured in 2i serum-free medium

ChEBI2012-04-26 更新2026-07-21 收录

干细胞多能性

表观转录组学

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-23943 数据链接链接失效反馈

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Epigenome and transcriptome of naive pluripotent mouse embryonic stem (ES) cells cultured in 2i serum-free medium

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创建时间：

2012-04-26

表观转录组学

染色质调控

The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (mRNA) in various biological processes. Here, we show that the knockout of the m6A writer Mettl3 or a

NIAID Data Ecosystem80

Transcriptome Mapping of Internal N7-methylguanosine Methylome in Mammalian mRNA

RNA甲基化

表观转录组学

N7-methylguanosine (m7G) is a positively charged, essential modification at the 5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m7G also occurs internally within tRNA and

NIAID Data Ecosystem40

m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [bulkRNA-seq]. m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [bulkRNA-seq]

表观转录组学

结肠上皮细胞

The function of m6A modification in colonic epithelial cells has been validated in our study that depletion of METTL14 in colonic epithelial cells triggers cell death. To further explore the biologica

NIAID Data Ecosystem40

hAEC are positive for naïve pluripotent markers.

干细胞多能性

免疫染色分析

(A) Representative micrographs at 20x from hAEC at P0-P2 immunostained for KLF4 (red) and TFE3 (red); the nuclei were stained with DAPI (blue). (B) Graph shows the percentage of hAEC that express naïv

NIAID Data Ecosystem60

Mass spectrometry on tRNAs from Tet1/2/3 tKO mESCs rescued with TET2 WT or catalytic mutant (HxD) and control (GFP)

tRNA修饰

表观转录组学

Mass spectrometry analysis on tRNAs gel purified from Tet1/2/3 triple KO mouse embryonic stem cells after transient transfection of TET2 catalytic fragment wild type (WT), catalytic mutant (HxD), or a

Figshare2020-10-23 更新40

Epigenome and transcriptome of naive pluripotent mouse embryonic stem (ES) cells cultured in 2i serum-free medium

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