Summary of A. nidulans protein kinase classification and phenotypes.

Group abbreviations: AGC (protein kinase A, G or C); CK1 (casein kinase 1); CAMK (Ca2+/calmodulin-dependent protein kinase); CMGC (cyclin-dependent, mitogen-activated, glycogen synthase and cyclin-dependent protein kinase-like kinases); STE (sterile kinases); HisK (histidine kinase). Family abbreviations: Akt (oncogene protein of v-akt); NDR (nuclear Dbf2 related); PDK1(phosphoinoside-dependent protein kinase); PKA (protein kinase A); PKC (protein kinase C); RSK (ribosomal S6 kinase); YANK (yet another novel kinase); CAMKL (CAMK-like kinase); CK (casein kinase); CDK (cyclin-dependent protein kinase); CLK (CDK-like kinase); DYRK, (dual-specificity tyrosine phosphorylation-regulated kinase); GSK (glycogen synthase kinase); MAPK (mitogen-activated protein kinase); RCK (related to murine RCK); SRPK (serine-arginine protein kinase); AUR (Aurora); CAMKK (CAMK kinase); CDC (cell division cycle); HAL (halotolerance); IRE (inositol-requiring protein); NAK (NF-κB-activating kinase); NEK (NIMA-related kinase); PEK (pancreatic alpha-subunit of eukaryotic initiation factor kinase); PLK (polo kinase); RAN (Ran GTPase kinase); SCY1 (related to S. cerevisiae Scy1 kinase); ULK (Unc-51-like kinase); VPS (vacuolar protein sorting); WEE (small); IKS (Ira1 kinase suppressor); PDHK (pyruvate dehydrogenase kinase); PIKK (phosphatidyl inositol kinase-related kinase); RIO (right open reading frame); TTK (Tau Tubulin Kinase). Other abbreviations: Ank = contains ankyrin repeat domains; HU = HU sensitive; Camp = Camptothecin sensitive; DEO = DEO sensitive; Ben = benomyl sensitive; NaCls = growth inhibition in the presence of NaCl; Sucs = growth inhibition in the presence of 1.5 M sucrose; NaClRem = defects remediated on NaCl; SucRem = defects remediated on sucrose; Colony color = Abnormal colony color; Brown = brown pigment produced by colonies/microcolonies; Yellow = yellow pigment production; Cell cycle = cell cycle defect; k = kinase domain deletion; V = variability in phenotype; Het = also recovered heterokaryons; UN = unnamed; ND = not determined; BH = best hit by BlastP. * = named in this study.