PolyA RNA sequencing of soleus muscles of WT and LSD1-mKO mice after voluntary wheel running

To understand the role of LSD1 in transcriptional regulation in muscle under voluntary wheel running (VWR) training, RNA-seq analyses of soleus muscles of skeletal muscle-specific LSD1 KO mice (LSD1-mKO mice) and WT mice after VWR were carried out. We found that loss of LSD1 led to increased expression of oxidative metabolism genes in soleus muscle. Overall design: LSD1-mKO and WT mice were trained by voluntary wheel running.