riboCIRC

The database was developed which aims to provide: (1) a comprehensive repository of computationally predicted ribosome-associated circRNAs (Ribo-circRNAs); (2) a manually curated collection of experimentally verified translated circRNAs; (3) an evaluation of cross-species conservation of translatable circRNAs; (4) a systematic de novo annotation of putative circRNA-encoded peptides, and (5) a genome browser to visualize the context-specific occupant footprints of circRNAs. Currently the database contains a total of 2,247 computationally predicted translatable circRNAs across 6 different species (Human, Mouse, Rat, C.elegans, Drosophila and Zebrafish) and 216 experimentally verified translated circRNAs.本数据库旨在提供以下五项核心内容：(1) 核糖体关联环状RNA（ribosome-associated circRNAs，Ribo-circRNAs）的综合性计算预测存储库；(2) 经人工甄选整理的、经实验验证的可翻译环状RNA集合；(3) 可翻译环状RNA的跨物种保守性评估；(4) 推定环状RNA编码肽的系统性从头（de novo）注释；(5) 用于可视化环状RNA上下文特异性结合足迹的基因组浏览器。目前，该数据库共收录了覆盖6个物种（人、小鼠、大鼠、秀丽隐杆线虫、果蝇、斑马鱼）的2247条经计算预测的可翻译环状RNA，以及216条经实验证实的可翻译环状RNA。

搜集汇总

背景与挑战

背景概述

riboCIRC v2.0是一个专注于可翻译环状RNA（circRNAs）的多物种数据库，提供计算预测的核糖体相关circRNAs、实验验证的可翻译circRNAs、跨物种保守性评估、circRNA编码肽的系统注释以及基因组浏览器可视化功能。当前数据库包含85,828个计算预测的ribo-circRNAs和80个文献报道的trans-circRNAs，覆盖多个物种。