Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one

Crystal Structure of BPTF bromodomain in complex with 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one Descriptor: 1,2-ETHANEDIOL, 4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF Authors: Zahid, H, Buchholz, C, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. Deposit date: 2021-08-20 Release date: 2022-08-24 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.39 Å) Cite: New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J.Med.Chem., 64, 2021BPTF溴结构域（bromodomain）与4-氯-5-{4-[(二甲氨基)甲基]苯胺基}-2-甲基哒嗪-3(2H)-酮复合物的晶体结构 描述符：1,2-乙二醇(1,2-ETHANEDIOL)、4-氯-5-{4-[(二甲氨基)甲基]苯胺基}-2-甲基哒嗪-3(2H)-酮(4-chloro-5-{4-[(dimethylamino)methyl]anilino}-2-methylpyridazin-3(2H)-one)、核小体重塑因子亚基BPTF(Nucleosome-remodeling factor subunit BPTF) 作者：Zahid, H、Buchholz, C、Johnson, J.A、Shi, K、Aihara, H、Pomerantz, W.C.K. 提交日期：2021-08-20 发布日期：2022-08-24 最后修改日期：2023-10-18 实验方法：X射线衍射(X-RAY DIFFRACTION)，分辨率1.39埃(Å) 引用文献：《通过BPTF溴结构域抑制作用开发强效核小体重塑因子（NURF）细胞活性抑制剂的新型设计规则》，《药物化学杂志》（J.Med.Chem.），2021年，第64卷