Biophysically detailed mathematical models of cardiac electrophysiology provide an alternative to experimental approaches for investigating possible ionic mechanisms underlying the genesis of electric

NIAID Data Ecosystem30

Data_Sheet_2_Mechanisms Underlying Interactions Between Low-Frequency Oscillations and Beat-to-Beat Variability of Celullar Ventricular Repolarization in Response to Sympathetic Stimulation: Implications for Arrhythmogenesis.zip

心脏电生理建模

心律失常机制

Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization (BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental studies on human left vent

NIAID Data Ecosystem20

Heart failure ionic remodeling.

心脏电生理建模

心力衰竭离子重塑

Changes in original Grandi et al. (GPB) [34] and O'Hara et al. (ORd) [35] models to simulate heart failure (HF) phenotype. The modified parameters are: the late Na+ current (INaL), the time constant o

NIAID Data Ecosystem40

Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue

心脏电生理建模

心律失常预测

Ectopic heartbeats can trigger reentrant arrhythmias, leading to ventricular fibrillation and sudden cardiac death. Such events have been attributed to perturbed Ca2+ handling in cardiac myocytes lead

Figshare2017-11-17 更新20

OVVR model parameters that fit I<sub>Na</sub> behavior for WT and <i>SCN5A</i> mutations.

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