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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy - all quantitative data - CDD - Rousseaux lab Feb 2024

NIAID Data Ecosystem2026-05-01 收录

突触核蛋白病

CDK14靶点研究

数据链接：

https://zenodo.org/record/10654886 数据链接链接失效反馈

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资源简介：

This is the excel file containing all quantative data for the manuscript "Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy" by the Rousseaux lab.

应用场景：

创建时间：

2024-02-13

突触核蛋白病

肠-脑轴

We generated a digital spatial profiling (DSP) dataset from duodenal myenteric plexus of 3-month-old 3KL and WT mice, analyzing 2â3 ROIs per slide across 2 animals per genotype. The dataset comprise

DataONE2025-12-03 更新110

Idiopathic normal pressure hydrocephalus with synucleinopathy: diagnosis and treatment

特发性正常压力脑积水

突触核蛋白病

PearlsÂ -Â Â Â Idiopathic normal pressure hydrocephalus (iNPH) is characterized by the classic triad of gait disturbance, urinary incontinence, and cognitive impairment in the presence of ventriculo

DataONE2021-10-21 更新50

Data_Sheet_3_Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.xlsx

炎症机制

突触核蛋白病

Alpha-synuclein (αSynAgg) are pathological hallmarks of Parkinson's disease (PD) and other synucleinopathies that induce microglial activation and immune-mediated neurotoxicity, but the molecular mech

NIAID Data Ecosystem10

Single cell RNA sequencing analysis of midbrain organoids with SNCA gene triplication modeling key features of synuclienopathy

单细胞RNA测序

突触核蛋白病

SNCA, the first gene associated with Parkinson's disease, encodes the a-synuclein protein, the predominant component within pathological inclusions termed Lewy bodies. We use 3D midbrain organoids, di

NIAID Data Ecosystem60

Genome-Wide Profiling of DNA Methylation and Gene Expression induced by Alpha-Synuclein in Murine Microglia [RNA-seq]. Genome-Wide Profiling of DNA Methylation and Gene Expression induced by Alpha-Synuclein in Murine Microglia [RNA-seq]

突触核蛋白病

小胶质细胞转录组

BACKGROUND: Synucleinopathy disorders are characterized by aggregates of α-synuclein (α-syn), which engage microglia to elicit a neuroinflammatory response. However, the influence α-syn has on DNA met

NIAID Data Ecosystem40

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy - all quantitative data - CDD - Rousseaux lab Feb 2024

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