11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one

11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one Descriptor: (4S)-4-(2-methoxyphenyl)-3,3-dimethyl-1-[3-(methylsulfonyl)phenyl]azetidin-2-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: McCoull, W, Augustin, M, Blake, C, Ertan, A, Kilgour, E.K, Krapp, S, Moore, J.E, Newcombe, N.J, Packer, M.J, Rees, A, Revill, J, Scott, J.S, Selmi, N, Gerhardt, S, Ogg, D.J, Steinbacher, S, Whittamore, P.R.O. Deposit date: 2013-11-15 Release date: 2014-03-26 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) TO BE PUBLISHED11-β-HSD1（11-beta-HSD1）与3,3-二甲基氮杂环丁-2-酮形成的复合物。描述符：(4S)-4-(2-甲氧基苯基)-3,3-二甲基-1-[3-(甲基磺酰基)苯基]氮杂环丁-2-酮、皮质类固醇11β-脱氢酶同工酶1（Corticosteroid 11-beta-dehydrogenase isozyme 1）、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）……作者：McCoull, W、Augustin, M、Blake, C、Ertan, A、Kilgour, E.K、Krapp, S、Moore, J.E、Newcombe, N.J、Packer, M.J、Rees, A、Revill, J、Scott, J.S、Selmi, N、Gerhardt, S、Ogg, D.J、Steinbacher, S、Whittamore, P.R.O. 存档日期：2013-11-15；发布日期：2014-03-26；最后修改日期：2024-02-28；实验方法：X射线衍射（2.9 Å）；引用文献：《3,3-二甲基氮杂环丁-2-酮类强效选择性11β-羟基类固醇脱氢酶1型（11-beta-HSD1）抑制剂的鉴定与优化》（待发表）