Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH AND Cycloguanil Descriptor: 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Chitnumsub, P, Yuvaniyama, J, Yuthavong, Y. Deposit date: 2009-08-24 Release date: 2010-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase To be Published克氏锥虫（Trypanosoma cruzi）二氢叶酸还原酶-胸苷酸合酶与还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及环氯胍（Cycloguanil）复合物 描述符：1-(4-氯苯基)-6,6-二甲基-1,6-二氢-1,3,5-三嗪-2,4-二胺、双功能二氢叶酸还原酶-胸苷酸合酶、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）…… 作者：Chitnumsub, P、Yuvaniyama, J、Yuthavong, Y 提交日期：2009-08-24 发布日期：2010-07-28 最后修改日期：2023-09-06 实验方法：X射线衍射（分辨率2.6 Å） 引用：《抗叶酸药物抑制克氏锥虫二氢叶酸还原酶-胸苷酸合酶的结构基础》（待发表）