Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised
Fixed effects: age category (mother, pup), tissue (brain, muscle, oocyte pool, single oocyte [combined across all oocytes measured for a mouse]), mtDNA compartment (D-loop, non–D-loop), mutation type
Duplex sequencing of mtDNA from rhesus macaque somatic tissues (liver, skeletal muscle, and heart), and single oocytes was performed to study the effect of aging on mtDNA substitution frequencies. Mac
