Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design

Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04691502 through Structure Based Drug Design Descriptor: 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Knighton, D.R. Deposit date: 2010-04-16 Release date: 2010-06-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett, 4, 2013基于结构药物设计发现高活性磷脂酰肌醇3-激酶/雷帕霉素靶蛋白（PI3K/mTOR）双重抑制剂PF-04691502 描述符：2-氨基-8-[反式-4-(2-羟基乙氧基)环己基]-6-(6-甲氧基吡啶-3-基)-4-甲基吡啶并[2,3-d]嘧啶-7(8H)-酮 磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ亚型 作者：奈顿（Knighton, D.R.） 提交日期：2010-04-16 发布日期：2010-06-02 最后修改日期：2024-02-21 实验方法：X射线衍射（分辨率2.55埃） 引用文献：基于结构药物设计发现高活性PI3K/mTOR双重抑制剂PF-04979064，《ACS药物化学快报》，第4卷，2013年