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Dynamics of amyloid protein fibril elongation using isotope-labelled SANS

B2FIND2026-04-25 收录

淀粉样蛋白聚集

蛋白质表征

数据链接：

https://b2find.eudat.eu/dataset/d00d4ff9-a1a6-5a7e-9cca-8d6dd908efd1 数据链接链接失效反馈

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资源简介：

This proposal combines small-angle neutron scattering with novel labelling strategies to investigate amyloid protein fibrils. Variations in packing and in the dynamics of...

应用场景：

蛋白质结构建模与模拟

淀粉样蛋白聚集

SL marks single layer decamers and DL double layer decamers. The symbol * marks the mixed rat-human amylin complexes, where the first five strands are from the human amylin sequences and the last five

NIAID Data Ecosystem80

Following the structural changes in a freeze-dried protein resulting from rehydration and change in temperature

蛋白质表征

生物制药稳定性

Using SAXS/WAXS, we intend to investigate the overall structural changes in the therapeutic protein, ‘Palifermin’ when it is re-hydrated after freeze-drying to different hydration levels at a fixed te

ESRF Portal2026-01-01 更新50

Amyloid-βpeptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane

淀粉样蛋白聚集

神经元膜-蛋白相互作用

Mounting evidence suggests that the neuronal cell membrane is the main site of oligomer-mediated neuronal toxicity of amyloidβ-peptides in Alzheimer’s disease. This study aims at gaining detailed unde

Mendeley Data2021-07-23 更新20

Face to face contact distances of CC interface double layers of human amylin, rat amylin and their cross-seeded oligomers (human amylin|rat amylin).

淀粉样蛋白聚集

粒子间距离分析

Hydrophobic contact of Cα−Cα distances (Å) between the residues L27/G33, S29/N31, N31/S29 and G33/L27 of human amylin and L27/G33, P29/N31, N31/P29 and G33/L27 of rat amylin and their hetero-assembly.

NIAID Data Ecosystem50

a-Synuclein short MD simulations:A53T[A-G]

分子动力学模拟

淀粉样蛋白聚集

Short molecular dynamics simulations of a-Synuclein amyloids, A53T[A-G]

Figshare2018-08-25 更新40