liCHi-C data from young and old hippocampal neurons

Aging is a multi-factorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes in 3D genome organization and its impact in gene transcription, as well as the effect of external interventions on this process, remains limited. Here we describe changes in the landscape of the 3D chromatin interactome upon aging, utilizing the low input Promoter Capture Hi-C (liCHi-C) technique with hippocampal neurons. We integrated liCHi-C data with RNA-seq data to identify functional implications at the transcriptome level. Furthermore, we assessed the effect of exposure to environmental stimulation (ES).