Transcriptional profiling of E14.5 control and Tbr2 fl/fl;Foxg1::Cre cortices

The abscence of TBR2 gene in human leads to microcephaly. This condition is mimicked by the specific ablation of the murine gene in developing cerebral cortex. Herein we compared gene expression in control and Tbr2 cKO in E14.5 cerebral cortices. This approach represents a useful tool to identify the molecular mechanisms at the basis of the phenotype. 6 samples, 3x Tbr2 +/+;Foxg1::Cre (control) and 3x Tbr2 fl/fl;Foxg1::Cre人类TBR2基因（TBR2 gene）的缺失可导致小头畸形（microcephaly）。在发育中的小鼠大脑皮层中特异性敲除该小鼠Tbr2同源基因，即可模拟该病症。本研究针对胚胎第14.5天（E14.5）的小鼠大脑皮层样本，对比分析了对照组与Tbr2条件性敲除（Tbr2 cKO）组的基因表达水平。该研究策略可为解析该表型背后的分子机制提供有效工具。本数据集共包含6个样本：3组为Tbr2 +/+;Foxg1::Cre（对照组），剩余3组为Tbr2 fl/fl;Foxg1::Cre。