Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C

Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C Descriptor: (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... Authors: Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. Deposit date: 2017-03-23 Release date: 2018-02-07 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell, 172, 2018小分子ARS-1620与K-Ras G12C共价结合的晶体结构 描述符：(S)-1-{4-[6-氯-8-氟-7-(2-氟-6-羟基苯基)喹唑啉-4-基]哌嗪-1-基}丙-1-酮、钙离子（CALCIUM ION）、甘油（GLYCEROL）等 作者：Janes, M.R、Zhang, J、Li, L.-S、Hansen, R、Peters, U、Guo, X、Chen, Y、Babbar, A、Firdaus, S.J、Feng, J、Chen, J.H、Li, S、Brehmer, D、Darjania, L、Li, S、Long, Y.O、Thach, C、Liu, Y、Zarieh, A、Ely, T、Kucharski, J.M、Kessler, L.V、Wu, T、Wang, Y、Yao, Y、Deng, X、Zarrinkar, P、Dashyant, D、Lorenzi, M.V、Hu-Lowe, D、Patricelli, M.P、Ren, P、Liu, Y 沉积日期：2017-03-23 发布日期：2018-02-07 最后修改日期：2024-10-30 实验方法：X射线衍射（X-RAY DIFFRACTION，1.38 Å） 引用文献：《靶向携带G12C突变KRAS的癌症的G12C特异性共价抑制剂》，《细胞（Cell）》，172卷，2018年