Highly Selective Dopamine D<sub>3</sub> Receptor Antagonists with Arylated Diazaspiro Alkane Cores
收藏NIAID Data Ecosystem2026-03-10 收录
数据链接：
官方服务：
资源简介：
A series of potent and selective D3 receptor (D3R) analogues with diazaspiro alkane cores were synthesized. Radioligand binding of compounds 11, 14, 15a, and 15c revealed favorable D3R affinity (Ki = 12–25.6 nM) and were highly selective for D3R vs D3R (ranging from 264- to 905-fold). Variation of these novel ligand architectures can be achieved using our previously reported 10–20 min benchtop C–N cross-coupling methodology, affording a broad range of arylated diazaspiro precursors.
创建时间：
2017-11-21
