Targeting the sympathetic nervous system to reduce the progression of breast cancer

Breast cancer is the most common cancer in women globally, with 1 in 7 Australian women diagnosed before age 85. Tumours contain various cells and networks, including nerves. Recent research shows chronic stress signals from the sympathetic nervous system (SNS) can worsen cancer. This thesis explores the role of the SNS in breast cancer using mouse models. Radiotherapy was found to increase SNS activity, but blocking the SNS improved treatment. Exercise reduced SNS activity and slowed cancer, despite the stress of social isolation. Reducing chronic SNS signalling through pharmacological and lifestyle interventions may help combat breast cancer.