DNA methylation patterns of neuroendocrine neoplasms

Neuroendocrine neoplasms (NEN) are thought to originate from diffuse endocrine networks and therefore most frequently occur in the gastrointestinal tract and lungs. The liver is a frequent site of metastasis of NEN but also the presence of primary hepatic NEN (PHNEN) has been proposed. Due to the impact on disease management, it is urgently required to discriminate the origin of hepatic NEN metastases and to identify clinically relevant subgroups. A set of 15 PHNEN was analyzed by Illumina DNA methylation.