zhaoguoqing/Tahoe-100M

Tahoe-100M是一个千兆级别的单细胞扰动图谱，包含来自50种癌细胞系暴露于1,100种小分子扰动的超过1亿个转录组图谱。该数据集由Vevo Therapeutics的Mosaic高通量平台生成，能够在前所未有的规模和分辨率下深入、上下文感知地探索基因功能、细胞状态和药物反应。该数据集旨在推动下一代细胞生物学AI模型的开发，在系统生物学、药物发现和精准医学等领域具有广泛的应用。Tahoe-100M is a gigascale single-cell perturbation atlas containing over 100 million transcriptomic profiles derived from 50 cancer cell lines exposed to 1,100 small-molecule perturbations. Generated using Vevo Therapeutics’ Mosaic high-throughput platform, this dataset enables in-depth, context-aware investigation of gene function, cellular states and drug responses at an unprecedented scale and resolution. Aimed at advancing the development of next-generation AI models for cell biology, the dataset has broad applications across fields including systems biology, drug discovery and precision medicine.