Additional file 3: of How do researchers determine the difference to be detected in superiority trials? Results of a survey from a panel of researchers
BACKGROUND: Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some researchers have found numerous defic
Background Phase II clinical trials are a cornerstone of the development in experimental treatments They work as a "filter" for phase III trials confirmation. Surprisingly the attrition ratio in Phase