Crystal Structure of BACE with Compound 6

Crystal Structure of BACE with Compound 6 Descriptor: 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... Authors: Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. Deposit date: 2011-10-28 Release date: 2012-04-18 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012

化合物6与BACE的晶体结构描述符：1,2-乙二醇（1,2-ETHANEDIOL）、β位淀粉样前体蛋白裂解酶1（Beta-secretase 1, BACE1）、二（羟乙基）醚（DI(HYDROXYETHYL)ETHER）等。作者：Efremov I.V、Vajdos F.F、Borzilleri K、Capetta S、Dorff P、Dutra J、Mansour M、Oborski C、O'Connell T、O'Sullivan T.J、Pandit J、Wang H、Withka J。存档日期：2011-10-28；发布日期：2012-04-18；最后修改日期：2024-10-09。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.51埃）。引用文献：《基于片段药物设计发现并优化新型螺吡咯烷类β位淀粉样前体蛋白裂解酶1（BACE1）抑制剂》，《J.Med.Chem.》，2012年，第55卷。