Mechanisms Coordinating Ribosomal Protein Gene Transcription in Response to Stress

In this study, we elucidate the common logic of the RPGs regulatory network by evaluating both the architecture and activity of promoters under conditions of stress or modulation of TF levels, and we identified the proteins regulating the activity of promoters lacking Rap1 binding, thus demonstrating that RPG co-regulation requires the complementary action of two different mechanisms involving both Ifh1 and Sfp1.本研究中，我们通过评估胁迫条件或转录因子（Transcription Factor, TF）水平调控下的启动子结构与活性，阐明了核糖体蛋白基因（Ribosomal Protein Genes, RPGs）调控网络的共同逻辑；同时鉴定了可调控缺乏Rap1结合位点的启动子活性的蛋白质，进而证实核糖体蛋白基因的共调控需要涉及Ifh1与Sfp1的两种不同机制的协同互补作用。