SM-TF database

SM-TF is a Small Molecule-Transcription Factor structural database.The SM-TF database collects available 3D structures of small molecule-transcription factor complexes from Protein Data Bank (PDB). Totally, SM-TF contains 934 entries, covering 176 TFs from a variety of species.SM-TF serves as a targetable TF database to assist structure-based drug design. The database is suitable for both traditional virtual screening (searching potential ligands for a given target) and inverse virtual screening (searching potential targets for a given ligand).SM-TF是小分子-转录因子（Small Molecule-Transcription Factor）结构数据库。该数据库从蛋白质数据银行（Protein Data Bank，PDB）中收录了已公开的小分子-转录因子复合物三维结构，总计包含934条条目，涵盖来自多个物种的176种转录因子。SM-TF作为可靶向转录因子数据库，可辅助基于结构的药物设计。该数据库既适用于传统虚拟筛选（为特定靶点搜寻潜在配体），也适用于反向虚拟筛选（为特定配体搜寻潜在靶点）。

搜集汇总

背景与挑战

背景概述

SM-TF数据库是一个收集小分子与转录因子复合物3D结构的数据资源，包含来自PDB的934个条目，覆盖176个不同物种的转录因子。该数据库旨在支持基于结构的药物设计，适用于传统和反向虚拟筛选方法。