Targeting of SMARCA4 bromodomain selectively inhibits leukemic cell proliferation

ChEBI2015-07-12 更新2026-07-12 收录

白血病靶向治疗

癌症表观遗传药物

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Targeting of SMARCA4 bromodomain selectively inhibits leukemic cell proliferation

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2015-07-12

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

Additional file 2: of Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair

白血病靶向治疗

癌症基因组数据

Table S1. List of all genes that were differentially expressed in cells exposed to MI-3, chidamide, or both, in which 635 overlapped genes shown in the Venn Diagram (Figure 3C) as well as 59 genes ind

Figshare2024-03-01 更新20

Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity

白血病靶向治疗

BRAF抑制剂药效评估

Braf inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia, and exert anti-leukemic activity

ChEBI2014-12-12 更新00

Discovery of Novel 5‑Cyano-3-phenylindole-Based LSD1/HDAC Dual Inhibitors for Colorectal Cancer Treatment

结直肠癌靶向治疗

癌症表观遗传药物

The dual inhibition of histone lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) has emerged as a promising strategy for cancer therapy. In this study, we report the discovery of nov

NIAID Data Ecosystem20

G9a in complex with the S-isomer of RK-131902 (racemic compound rac-10a)

蛋白质-配体复合物结构

癌症表观遗传药物

G9a in complex with the S-isomer of RK-131902 (racemic compound rac-10a) Descriptor: Histone-lysine N-methyltransferase EHMT2, SINEFUNGIN, ZINC ION, ... Authors: Niwa, H, Shirai, F, Sato, S, Nishigaya

Protein Data Bank Japan2025-06-04 更新00

Targeting of SMARCA4 bromodomain selectively inhibits leukemic cell proliferation

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