Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor

Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor Descriptor: (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID, Ubiquitin-protein ligase E3 Mdm2 Authors: Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. Deposit date: 2004-04-29 Release date: 2005-02-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005人类MDM2与苯二氮䓬类抑制剂的复合物结构 描述符：(4-氯苯基)[3-(4-氯苯基)-7-碘-2,5-二氧代-1,2,3,5-四氢-4H-1,4-苯并二氮杂䓬-4-基]乙酸，泛素-蛋白连接酶E3 Mdm2（Ubiquitin-protein ligase E3 Mdm2） 作者：Grasberger, B.L.、Schubert, C.、Koblish, H.K.、Carver, T.E.、Franks, C.F.、Zhao, S.Y.、Lu, T.、LaFrance, L.V.、Parks, D.J. 提交日期：2004-04-29 发布日期：2005-02-08 最后修改日期：2023-08-23 解析方法：X射线衍射（分辨率2.6埃） 引用文献：《可激活细胞内p53的苯二氮䓬二酮类HDM2拮抗剂的发现及其共晶体结构》，《药物化学杂志》（J. Med. Chem.），第48卷，2005年