CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin

CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... Authors: Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. Deposit date: 2023-04-11 Release date: 2023-08-30 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor. Neuron, 111, 2023人源rho1型γ-氨基丁酸A型受体（GABAA receptor）与孔道阻断剂印防己毒素（picrotoxin）结合的冷冻电镜（CryoEM）结构 描述物：(1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-羟基-8b-甲基-9-(丙-1-烯-2-基)六氢-3,6-桥亚甲基-1,5,7-三氧杂环戊烷[ij]环丙[a]薁-4,8(3H)-二酮、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、癸烷（DECANE）等 作者：Chen, F、Victor, T、John, C、Rebecca, J.H、Lindahl, E 提交日期：2023-04-11 发布日期：2023-08-30 最后修改日期：2025-07-02 实验方法：电子显微镜（ELECTRON MICROSCOPY），分辨率2.9埃（Å） 引用文献：《人源rho型GABAA受体差异化配体结合的结构与动力学》，《神经元（Neuron）》，第111卷，2023年