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Organocatalytic 1,4-Addition of Azadienes with 3‑Homoacyl Coumarins toward Highly Enantioenriched Benzofuran Coumarin Skeletons

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Figshare2020-09-04 更新2026-04-28 收录
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A highly enantioselective 1,4-addition reaction of azadiene with 3-homoacyl coumarin has been accomplished by low amounts of bifunctional cinchona alkaloid catalysis under mild conditions. Varieties of benzofuran coumarin skeletons were obtained in moderate to high yields (up to 99%) with excellent enantioselectivities (up to 99% ee) and complete diastereoselectivity.

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2020-09-04
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