GDP-bound KRAS G12D in complex with YK-8S

GDP-bound KRAS G12D in complex with YK-8S Descriptor: 1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-3-oxidanyl-propan-1-one, GTPase KRas, N-terminally processed, ... Authors: Zhang, Z.M, Wang, R.L. Deposit date: 2023-05-23 Release date: 2024-01-31 Last modified: 2025-09-24 Method: X-RAY DIFFRACTION (2.10004053415 Å) Cite: Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023GDP结合型KRAS G12D与YK-8S复合物 描述项：1-[4-[7-(8-乙炔基-7-氟萘-1-基)-8-氟-2-[[(2R,8S)-2-氟-1,2,3,5,6,7-六氢吡咯里嗪-8-基]甲氧基]吡啶并[4,3-d]嘧啶-4-基]哌嗪-1-基]-3-羟基丙-1-酮，经N端加工的GTP酶KRas，…… 作者：张 Z.M、王 R.L. 提交日期：2023-05-23 发布日期：2024-01-31 最后修改日期：2025-09-24 实验方法：X射线衍射（分辨率2.10004053415 Å） 引用文献：《可调节环氧乙烷亲电试剂同时共价修饰K-Ras(G12D)与K-Ras(G12C)》，《美国化学会志》，第145卷，2023年