Crystal structure of human KRAS G12C covalently bound to Divarasib (GDC6036)

Crystal structure of human KRAS G12C covalently bound to Divarasib (GDC6036) Descriptor: 1-{(3S)-4-[(7M)-7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-4-yl]-3-methylpiperazin-1-yl}propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... Authors: Fernando, M.C. Deposit date: 2024-09-13 Release date: 2025-05-21 Last modified: 2025-05-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structure of KRAS G12C bound to divarasib highlights features of potent switch-II pocket engagement. Small Gtpases, 15, 2024人源KRAS G12C与Divarasib（GDC6036）共价结合的晶体结构 描述符：1-{(3S)-4-[(7M)-7-[6-氨基-4-甲基-3-(三氟甲基)吡啶-2-基]-6-氯-8-氟-2-{[(2S)-1-甲基吡咯烷-2-基]甲氧基}喹唑啉-4-基]-3-甲基哌嗪-1-基}丙-1-酮、鸟苷-5'-二磷酸（Guanosine-5'-Diphosphate）、GTP酶KRas的2B亚型…… 作者：Fernando, M.C. 存档日期：2024-09-13 发布日期：2025-05-21 最后修改日期：2025-05-28 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9 Å 引用文献：KRAS G12C与Divarasib结合的结构揭示强效开关II口袋结合特征，《Small GTPases》，第15卷，2024年