Evaluation of cytotoxic and genotoxic activities in the bone marrow of mice treated with sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl}-benzenesulfonamide (CPN) based on MNPCE and PCE/NCE frequency.
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1 Negative control: dimethylsulfoxide (DMSO) 0.1 mL/10 g body weight (b.w.). 2 Positive control: mitomycin C (MMC) 4 mg/kg (80% LD50). All values are mean ± SD of five mice. 3 Statistical analysis: one-way ANOVA and the Tukey’s test. 4 Statistical analysis: chi-square (χ2) test. Mean values followed by the same letter in the column do not present significant difference at 5% probability. a, b, c, d Letter in common in the same column do not present significant difference (p > 0.05). Different letters in the same column present significant difference (p < 0.05). Evaluation of cytotoxic and genotoxic activities in the bone marrow of mice treated with sulfonamide chalcone N-{4-[3-(4-nitrophenyl)prop-2-enoyl]phenyl}-benzenesulfonamide (CPN) based on MNPCE and PCE/NCE frequency.
