File S1 - The Influence of Pathological Mutations and Proline Substitutions in TDP-43 Glycine-Rich Peptides on Its Amyloid Properties and Cellular Toxicity

Supporting Information File. Table S1. Summary of the biophysical/biological characteristics of the TDP-43 C-terminal mutant and proline substituents fragments. Figure. S1 Co-incubation of GGG308PPP with pathological mutant G295S resulted in massive amorphous aggregate formation. Electron micrographs of (A) G295S only or (B) co-incubated with GGG308PPP in a 4∶1 molar ratio at 37°C. Fibril solutions were negatively stained with 2% uranyl acetate and observed by Hitachi H-7000 electron microscope. The scale bars represent 100 nm. (DOC)