Enantioselective Synthesis of Chiral α‑Thio-Quaternary Stereogenic Centers via Phase-Transfer-Catalyzed α‑Alkylation of α‑Acylthiomalonates
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资源简介：
An efficient synthetic method for establishing chiral α-thio-α-quaternary stereogenic center was successfully developed. The enantioselective α-alkylation of α-acylthiomalonates under phase-transfer catalytic conditions [50% aq. KOH, toluene, −20 °C, and (S,S)-3,4,5-trifluorophenyl-NAS bromide] provided the corresponding α-acylthio-α-alkylmalonates in high chemical yields (up to 99%) and high optical yields (up to 98% ee).
创建时间：
2018-01-10
