Overall haplotype association analysis for heroin dependence.

Overall haplotype association analysis for heroin dependence comparing the heroin dependent group (HER) with the combined control (CON) group. Each SNP included in a haplotype association test is denoted by ‘X’. P-value computed by the likelihood ratio test is the average of all possible haplotypes of an association and this was corrected by the Bonferroni method (PCorr) and global permutation test (PGlobal). Number of resampled datasets showing significant associations after the Bonferroni correction was counted (PCorr < 0.05). Only haplotypes maintaining significant association with heroin dependence after the Bonferroni correction and global permutation test are shown in the table. a Haplotypes that only contain SNPs in the S1-S29 segment (S1, S3, S5, and S29) are shown in bold font. Overall haplotype association analysis for heroin dependence.