Clusters of Orthologous Groups of Proteins: Phylogenetic classification of proteins encoded in complete genomes

Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.

蛋白质直系同源簇（Clusters of Orthologous Groups of proteins, COGs）是通过比对完整基因组所编码的蛋白质序列而界定的，此类完整基因组代表了主要的系统发育谱系。每个COG均包含来自至少3个谱系的单个蛋白质或旁系同源蛋白组，因此对应于一个古老的保守结构域。

搜集汇总

背景与挑战

背景概述

该数据集为蛋白质直系同源簇（COGs），通过比较完整基因组编码的蛋白质序列构建，涵盖主要系统发育谱系。每个COG包含至少三个谱系的蛋白质或旁系同源组，代表古老的保守结构域。