The co-crystal structure of DYRK2 with a small molecule inhibitor 7

The co-crystal structure of DYRK2 with a small molecule inhibitor 7 Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol Authors: Wei, T, Xiao, J. Deposit date: 2020-11-13 Release date: 2021-11-17 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.194 Å) Cite: Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022DYRK2（双特异性酪氨酸磷酸化调节激酶2，Dual specificity tyrosine-phosphorylation-regulated kinase 2）与小分子抑制剂7的共晶体结构 描述符：双特异性酪氨酸磷酸化调节激酶2，[2,7-二甲氧基-9-(哌啶-4-基甲硫基)吖啶-4-基]甲醇 作者：Wei, T、Xiao, J 提交日期：2020-11-13 发布日期：2021-11-17 最后修改日期：2024-11-20 实验方法：X射线衍射（分辨率2.194埃） 引用文献：《选择性抑制揭示DYRK2在蛋白质合成与钙内流中的调控功能》，《eLife》，第11卷，2022年