Results with p≤0.01for coronary heart disease and cardiovascular disease for the variants studied, analyzing men and women together.

aTime-to-event analysis, showing results for risk allele for the best model. Covariates used in analysis: geographic region, cohort, HDL-cholesterol, non-HDL cholesterol, body mass index, hypertension, smoking status, history of diabetes, and gender. P-values≤0.01 are in bold-face. P-values are not corrected for multiple testing. bResults for F12 rs4976691 are similar to those for rs17876032, since they are in almost perfect LD (r2>0.96).