Transcriptomic analysis of the hippocampus in Alzheimer’s disease

Purpose: The goal of this study is to compare NGS-derived transcriptome profiling (RNA-seq) in AD patients’ hippocampus. Methods: mRNA profiles of human hippocampus from AD patients and healthy controls were generated by deep sequencing, using Illumina GAIIx. Results: Using an optimized data analysis workflow, more than 20000 transcripts in hippocampus were detected. Top 6 genes were selected and related to “ion transport”. Correlation analysis demonstrated negative relationship of gene expression level with the neuropathologic changes. mRNA profiles of hippocampus in AD patients and healthy controls.