Spirochromane Akt Inhibitors

Spirochromane Akt Inhibitors Descriptor: Glycogen synthase kinase-3 beta, N-{(2S)-3-[(3S)-8',9'-dihydro-1H,3'H-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide, RAC-alpha serine/threonine-protein kinase Authors: Kallan, N.C, Spencer, K.L, Blake, J.F, Xu, R, Heizer, J, Bencsik, J.R, Mitchell, I.S, Gloor, S.L, Martinson, M, Risom, T, Gross, S.D, Morales, T, Vigers, G.P.A, Brandhuber, B.J, Skelton, N.J. Deposit date: 2011-02-01 Release date: 2011-03-30 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery and SAR of spirochromane Akt inhibitors. Bioorg.Med.Chem.Lett., 21, 2011螺色满类Akt抑制剂数据集说明：糖原合成酶激酶3β（Glycogen synthase kinase-3 beta）、N-{(2S)-3-[(3S)-8',9'-二氢-1H,3'H-螺[哌啶-3,7'-吡喃并[3,2-e]吲唑]-1-基]-2-羟丙基}-N-(2-乙氧基乙基)-2,6-二甲基苯磺酰胺、RAC-α丝氨酸/苏氨酸蛋白激酶 作者：Kallan, N.C、Spencer, K.L、Blake, J.F、Xu, R、Heizer, J、Bencsik, J.R、Mitchell, I.S、Gloor, S.L、Martinson, M、Risom, T、Gross, S.D、Morales, T、Vigers, G.P.A、Brandhuber, B.J、Skelton, N.J 入库日期：2011-02-01 发布日期：2011-03-30 最后修改日期：2024-11-06 检测方法：X射线衍射（1.9 Å） 引用文献：《螺色满类Akt抑制剂的发现与构效关系》，Bioorg.Med.Chem.Lett.，21卷，2011年