Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 20 (co-crystal)

Crystal structure of C-terminal Domain of MSK1 in complex with covalently bound pyrrolopyrimidine compound 20 (co-crystal) Descriptor: (5M)-5-(2,5-dichloropyrimidin-4-yl)-5H-pyrrolo[3,2-d]pyrimidine, Ribosomal protein S6 kinase alpha-5 Authors: Yano, J.K, Abendroth, J, Hall, A. Deposit date: 2022-04-14 Release date: 2022-07-06 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. Acs Med.Chem.Lett., 13, 2022与共价结合的吡咯并嘧啶类化合物20形成复合物的MSK1 C端结构域的晶体结构（共晶结构） 描述符：(5M)-5-(2,5-二氯嘧啶-4-基)-5H-吡咯并[3,2-d]嘧啶、核糖体蛋白S6激酶α-5 作者：Yano, J.K.、Abendroth, J.、Hall, A. 提交日期：2022-04-14 发布日期：2022-07-06 最后修改日期：2024-10-30 实验方法：X射线衍射（分辨率3 Å） 引用文献：《一类新型氯嘧啶类MSK1激酶共价抑制剂的发现与表征》，发表于《ACS药物化学快报》，2022年，第13卷