A variety of methods have been developed for the repression of gene expression using CRISPR-Cas systems, where a catalytically dead Cas protein (dCas) is used to regulate genes in an RNA-guided manner

NIAID Data Ecosystem60

Targeted modulation of chicken genes in vitro using CRISPRa and CRISPRi toolkit . Targeted modulation of chicken genes in vitro using CRISPRa and CRISPRi toolkit

CRISPR基因调控

鸡遗传学功能研究

To investigate the effectiveness of CRISPR based gene modulation, IRF7 was repressed in dCas9-KRAB DF1 cell line or activated in dCas9-VPR DF1 cell line followed by whole transcriptome analysis Overal

NIAID Data Ecosystem40

Fig_S9_S10_SwitchBack_Microfluidics

CRISPR基因调控

微流控成像

This file contains the microscopy images of the data in Fig. S9 and S10 for the following condition: 2 hours of CRISPRi induction (43% induction level) followed by inducers removal and the addition of

DataONE2018-09-13 更新70

Genome-wide gene expression analysis for CRISPRi targeting a human SFTPB locus bound by NKX2-1

CRISPR基因调控

SFTPB基因表达

RNA-seq was performed to identify genes affected by CRISPRi (dCas9-KRAB) with sgRNA (sgSFTPB#2) targeting the first intronic region of human SFTPB bound by NKX2-1 in an unbiased genome-wide fashion us

NIAID Data Ecosystem50

RNA-seq of an inducible whiA CRISPRi strain grown with 0 or 500 ng/mL anhydrotetracycline

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