y-mtPTM

To integrate information on PTMs of the mitochondrial proteome of the yeast Saccharomyces cerevisiae, we built the yeast mitochondrial posttranslational modification (y-mtPTM) database (http://compbio.fmph.uniba.sk/y-mtptm/). It lists nearly 20,000 positions on mitochondrial proteins affected by -20 various PTMs, with phosphorylated, succinylated, acetylated, and ubiquitylated sites being the most abundant. A simple search of a protein of interest reveals the modified amino acid residues, their position within the primary sequence as well as on its 3D structure, and links to the source reference(s).为整合酿酒酵母（Saccharomyces cerevisiae）线粒体蛋白质组的翻译后修饰（Posttranslational Modification, PTM）相关信息，我们构建了酿酒酵母线粒体翻译后修饰数据库（y-mtPTM），其访问网址为http://compbio.fmph.uniba.sk/y-mtptm/。该数据库收录了酿酒酵母线粒体蛋白上近20000个受约20余种不同翻译后修饰作用的位点，其中磷酸化、琥珀酰化、乙酰化及泛素化修饰位点最为丰富。用户仅需对目标蛋白进行简单检索，即可获取该蛋白的修饰氨基酸残基信息、其在蛋白质一级序列与三维结构上的具体定位，同时可获得相关参考文献的链接。

搜集汇总

背景与挑战

背景概述

y-mtPTM数据库整合了酿酒酵母线粒体蛋白质组的翻译后修饰（PTM）信息，收录了约20,000个受多种PTM影响的蛋白质位点，其中磷酸化、琥珀酰化、乙酰化和泛素化位点最为丰富。该数据库支持通过蛋白质名称、基因名称等搜索，提供修饰残基的序列位置、3D结构信息及相关文献链接。