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Enantioselective Synthesis of Dihydrospiro[indoline-3,4′-pyrano[2,3‑<i>c</i>]pyrazole] Derivatives via Michael/Hemiketalization Reaction

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NIAID Data Ecosystem2026-03-09 收录
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A new bifunctional squaramide organocatalyst derived from l-proline mediated the first enantioselective synthesis of dihydrospiro­[indoline-3,4′-pyrano­[2,3-c]­pyrazole] derivatives in excellent enantioselectivity by reacting pyrazolones with isatylidine β,γ-unsaturated α-ketoester. This new catalyst outperformed widely used thioureas and squaramides in inducing enantioselectivity.

创建时间:
2016-03-14
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