Cardiac remodeling is defined as changes in shape and function of the heart in response to aggression (pressure overload). The sarcoplasmic reticulum calcium ATPase cardiac isoform 2a (SERCA2a) is a k
Background. Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (E
Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are yet unknown. Research is hampered by t
Background: Low myocardial cGMP-PKG activity has been associated with increased cardiomyocyte diastolic stiffness in HFpEF. cGMP is mainly hydrolyzed by phosphodiesterases (PDE) 5a and 9a. Importantly