Gene expression profiling of Acute Myeloid Leukemia (AML) samples. Homo sapiens

The aim was to analyze the expression of genes in cytogenetically distinct cases of AML. Overall design: We used total RNA obtained from 6 AML samples, consisting of 3 cytogenetically distinct subtypes, to establish the expression levels of 27,868 individual human genes. Expression data from the ABI Human Genome Survey Microarray were filtered, quantile-normalized and subjected to significance analysis of microarrays. Established gene expression profiles were further compared with corresponding DNA methylation in analyzed AML patients.