miRNA expression in LGCIN outcomes. miRNA expression in LGCIN outcomes

The goal of this study was to investigate differential regulation of miRNA expression in the cervical tissue of women with low-grade cervical intraepithelial neoplasia (LGCIN, or low grade cervical dysplasia). We compared the miRNA expression profiles of women with LGCIN that progressed to high-grade CIN to the miRNA expression profiles of women with LGCIN that naturally resolved without medical intervention. Overall design: Study design was case-control without matching. Retrospective chart review was performed to identify women with prior diagnosis of low-grade cervical dysplasia. Women were included if they met inclusion criteria as a Case (women with definitive diagnosis of high-grade dysplasia) or Control (women with significant clinical evidence of dysplasia resolution without medical intervention). Archived punch biopsy specimens with histology consistent with low-grade cervical intraepithelial neoplasia were tested for miRNA expression. Analysis compared Case group to Control group.