Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice

RNA sequencing was performed to evaluate the impact of Dnm2 K562E mutation in the soleus muscle. The assessment of the dataset reveals a large number of differentially regulated transcripts between animals of both genotypes. This is consistent with a dominant phenotype caused by the Dnm2 K562E point mutation on the muscle. The dataset includes sequenced RNA extracted from soleus muscle of mice aged to 2 months. Soleus muscles were obtained from 4 independent male mice per genotype. The genotypes analyzed include controls (Dnm2+/+) and Dnm2 K562E point-mutant mice (Dnm2 +/K562E).本研究通过RNA测序（RNA sequencing）评估Dnm2 K562E点突变对小鼠比目鱼肌的影响。对本数据集的分析显示，两种基因型实验动物间存在大量差异调控的转录本，该结果与Dnm2 K562E点突变在肌肉组织中引发的显性表型相一致。本数据集包含提取自2月龄小鼠比目鱼肌的测序RNA样本。每组基因型均选取4只独立雄性小鼠获取比目鱼肌组织。本次分析涵盖的基因型包括野生型对照（Dnm2+/+）与Dnm2 K562E点突变小鼠（Dnm2 +/K562E）。