aFC_SQ: fold change in gene expression after peripheral (subcutaneous) leptin administration as compared to vehicle subcutaneous treatment. bFC_ICV: fold change in gene expression after central (intra
Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across
Leptin resistance during excess weigh gain significantly contributes to the recidivism of obesity to leptin-based pharmacological therapies. The mechanisms underlying the inhibition of Leptin receptor