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Principles of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling

Alliance of Genome Resources2026-08-01 收录

内质网共翻译易位机制

局部蛋白质合成

数据链接：

https://www.yeastgenome.org/dataset/GSE61012 数据链接链接失效反馈

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Localized protein synthesis is a fundamental mechanism for creating distinct subcellular environments

应用场景：

局部蛋白质合成

纤毛病

Cilia are microtubule-based hair-like organelles propelling locomotion and extracellular liquid flow or sensing environmental stimuli. As cilia are diffusion barrier-gated subcellular compartments, th

NIAID Data Ecosystem20

Identification of synaptoneurosomal transcriptome engaged into translation in response to NMDA-R stimulation

线粒体生物发生

局部蛋白质合成

Synapses are the regions of the neuron that enable the transmission and propagation of action potentials on the cost of high energy consumption and elevated demand for mitochondrial ATP production. Th

NIAID Data Ecosystem10

Protein local synthesis at synapse is required for neuromuscular transmission

神经肌肉接头突触翻译组

局部蛋白质合成

To profile the local translatome at the neuromuscular junction during various developmental stages We conducted RNA sequencing of synapse-enriched regions in the mouse diaphragms of both cre- and cre+

Alliance of Genome Resources00

Cilia locally synthesize proteins to sustain their ultrastructure and functions

纤毛生物学

局部蛋白质合成

NIAID Data Ecosystem20

Monosomes actively translate synaptic mRNAs in neuronal processes

局部蛋白质合成

mRNA信使RNA

In order to deal with their huge volume and complex morphology, neurons localize mRNAs and ribosomes near synapses to produce proteins locally. A relative paucity of polyribosomes (considered the acti

NIAID Data Ecosystem10

Principles of ER Co-Translational Translocation Revealed by Proximity-Specific Ribosome Profiling

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