The intracellular position of genes may impact their expression, but it has not been possible to accurately measure the 3D position of chromosomal loci. In 2D, loci can be tracked using arrays of DNA-
This file contains the source data for Extended Data Figure 1c. c, Hi-C matrix (at 5 kb resolution) and loops at the MRR1 region showing two looping silencers (S1 and S2) that exhibit chromatin intera
DNA replication occurs in units of chromatin higher order organization (Topologically Associating Domains, or TADs; replication domains, or RDs), which self-organize in 3D into sub-nuclear compartment
