Loss of cohesin in vivo alters adult stem cell homeostasis leading to myeloproliferative neoplasms

ChEBI2015-09-16 更新2026-07-12 收录

干细胞稳态调控

骨髓增殖性肿瘤病理机制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-72370 数据链接链接失效反馈

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资源简介：

Loss of cohesin in vivo alters adult stem cell homeostasis leading to myeloproliferative neoplasms

创建时间：

2015-09-16

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence by repressing MYC pathway activation [RXR_CnR]

干细胞稳态调控

MYC信号通路表观遗传学

Hematopoietic stem cells (HSCs) maintain homeostasis and fitness by balancing self-renewal and differentiation. Alterations to the symmetry of HSC divisions reduce quiescence and induce myeloid/megaka

NIAID Data Ecosystem70

Non-catalytic functions of Tet2 are essential to regulate hematopoietic stem and progenitor cell homeostasis. Non-catalytic functions of Tet2 are essential to regulate hematopoietic stem and progenitor cell homeostasis

干细胞稳态调控

Tet2非催化功能

To identify genes that are influenced by the catalytic and non-catalytic functions of Tet2 in hematopoietic stem and progenitor cells (HSPCs), we analyzed the gene expression profiles of Tet2 catalyti

NIAID Data Ecosystem60

The E3 ubiquitin ligase DDB1 controls homeostasis of hematopoietic stem and progenitor cells

干细胞稳态调控

E3泛素连接酶功能

The E3 ubiquitin ligase DDB1 controls homeostasis of hematopoietic stem and progenitor cells

ChEBI2015-07-10 更新30

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner

干细胞稳态调控

细胞非自主性调控

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner

ChEBI2011-04-26 更新60

STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion. STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion

干细胞稳态调控

骨髓增殖性肿瘤病理机制

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (IF

NIAID Data Ecosystem50

Loss of cohesin in vivo alters adult stem cell homeostasis leading to myeloproliferative neoplasms

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